It's become customary to give your protag a problem to deal with on top of the required crime to solve. He's accused of murder AND alcoholic. She's targeted for murder AND struggling with a cheating husband. More often than not, he or she is in physical danger AND harassed by a parent, living or dead, who screwed him or her up royally and made simple, day-to-day living difficult.
I won't comment on the American addiction to Blaming Parents for Absolutely Everything. But I notice that the problems tend to be psychological rather than physical. Now if your protag had a bad back, that would be truly limiting, as I can testify from the last few weeks. How about if she suffers from migraines? Spending the afternoon in a dark, quiet room isn't condusive to crime-solving. What if he has fallen arches? Glaucoma? Urinary incontinence?
Probably not. We prefer our demons to be mental, not physical. But in real life, I bet Kinsey and V.I. are getting to the age where they have find just the right sort of lighting or they'll never be able to read that clue.
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