I realize this is totally subjective, and no opinion is more valid than another, but here goes:
— I'm sick of Florida.
— I'm sick of New Orleans.
— I'm sick of New York City.
— I'm sick of England.
— I'm sick of Scandinavia, much sooner than I expected.
— I'm not quite burned out on L.A., but I see the day coming.
— I'm sick of quaint villages populated by white people only.
— I like the Pacific Northwest.
— I like the West.
— I like small cities with realistic ethnic diversity and realistic problems.
— I like underused locations. How often do you read about mysteries set in Kansas City? Or Dallas? Or Cleveland? Or the Carolinas?
Sub-questions: Where are you from? What informs your taste in settings? Will you ignore an otherwise recommended book if you don't care for the setting?